KMID : 0391520110190030199
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Journal of the Korean Child Neurology Society 2011 Volume.19 No. 3 p.199 ~ p.207
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Analysis of Urine Iodine Concentration by Inductively Coupled Plasma-mass Spectrometry Method in Normally Developed Children Aged Less than 7 Years in Masan City (Korea)
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Lee Jun-Hwa
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Abstract
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Purpose: Iodine is an essential component of thyroid hormones, and iodine deficiency disorder, including mental retardation, hypothyroidism, goiter, cretinism, and developmental abnormalities is the world¡¯s greatest single cause of preventable brain damage. Urine iodine (UI) is a sensitive indicator of recent changes in iodine intake. The objective of this study was to analyze the UI concentration in children younger than 7 years of age.
Methods: This population-based cross sectional study was conducted in four nurseries, three kindergartens, and the Samsung Changwon Hospital of Masan city in Korea from February to June 2010. Three hundred eighty-one samples of urine and 345 simple questionnaires were collected from normally developed preschool children less than 7 years of age. Urine samples were transferred to the Department of Laboratory Medicine at Samsung Seoul Hospital to measure UI concentration by inductively coupled plasma-mass spectrometry (ICP-MS) method.
Results: The median UI concentration was 327.9 ¥ìg/L (range 26.3-19,152.0 ¥ìg/L). There were 38 (10.0%) children with insufficient iodine intake (UI less than 100 ¥ìg/L). Of all children tested, the percentage of children with excessive iodine intake (UI over 300 ¥ìg/L) was 54.9%, and extremely high values exceeding 1,000 ¥ìg/L were found in 15.5 % of investigated children. There was a significant difference in the median UI concentration between three age groups (P<0.05) but no significance between males and females.
Conclusion: After measuring UI concentration, we report excessive iodine intake in preschool children less than 7 years of age in Masan city, Korea. In our population sample, we found that 10.0% of children had iodine deficiency.
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KEYWORD
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Urine iodine, Preschool, Korea, Mass Spectrometry method
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